When Ezra blessed the LORD at the reading of the Law, what did the people answer with uplifted hands?

Answer: "Amen, Amen!"

The people lifted their hands and said, "Amen, Amen!" Then they bowed and worshiped the LORD with their faces to the ground.

“Then Ezra blessed the LORD, the great God, and with their hands uplifted, all the people said, “Amen, Amen!” Then they bowed down and worshiped the LORD with their faces to the ground.”— Nehemiah 8:6 (BSB)